Mushure mekutanga, zvinhu zvinoiswa mutangi rekushandisa kuitira kutonhora. Kuomesa nechando kunosanganisira zvinhu zviviri: chekutanga, vacuum system inobvisa humwe unyoro nekudhirowa vacuum; chechipiri, sezvo zvinhu zvinotonhora, mamwe mamorekuru emvura anomanikidzwa kusvika pamusoro uye kuoma. Kana zvinodikanwa zvekuomesa nechando zvazadzikiswa, mudziyo wekudziya unopisa nekuomesa zvinhu, uchikweva vacuum kubvisa chero mwando wasara, unozotakurwa kuenda pariva rechando kuti uome, nokudaro kuwana kuoma kwechando{2}}zvinodiwa.
Kuomesa nechando-kuomesa kunoreva nzira yekubvisa mvura kana zvimwe zvinonyungudutsa kubva mumichero yakaomeswa nechando kuburikidza nekushomeka kwemvura. Sublimation (sublimation) inzira yekuti chinonyungudutsa, semvura, sechando chakaoma, chinoshanduka chakananga kubva pachinhu chakasimba kuenda panzvimbo ine gasi pasina kupfuura nepakati pemvura. Chigadzirwa chinowanikwa nechando-kuomeswa chinonzi lyophilizer, uye maitiro acho anodaidzwa kunzi findo-kuomesa. Kuomeswa kwechinyakare kunokonzera kupera kwezvinhu uye kukuvadza maseru. Munguva yekuomesa chando-kuoma, chimiro chemuenzaniso hachiparadzwe nekuti zvinhu zvakasimba zvinotsigirwa nechando panzvimbo yazvo. Sezvo ice sublimates, inosiya pores mune dzakaomeswa zvakasara. Izvi zvinochengetedza kutendeseka kwechigadzirwa chebiological uye chimiro chemakemikari nebasa racho. Murabhoritari, kuomesa chando{11}}kune maapplication akasiyana siyana uye kunokosha mukushandiswa kwakawanda kwebiochemical nemishonga. Inoshandiswa kuwana zvinhu zvebhayoloji zvinogona kuchengetedzwa kwenguva yakareba, senge twunhu tudiki diki, maenzayimu, ropa, nemishonga, zvichichengeta kwete chete kugadzikana kwazvo kwenguva refu chete asiwo maitiro azvo emubiology uye chimiro. Nechikonzero ichi, lyophilization inoshandiswa kugadzirira matishu masampula ezvidzidzo zvechimiro (senge electron microscopy). Lyophilization inoshandiswawo mukuongorora kemikari, ichipa masampuli akaomeswa kana kuisa sampuli kuwedzera analytical sensitivity. Lyophilization inodzikamisa zvikamu zvemuenzaniso pasina kushandura chimiro chavo chemakemikari, zvichiita kuti ive yakanaka yekuongorora rubatsiro. Lyophilization inogona kuitika zvakasikwa. Pasi pemamiriro echisikigo, iyi nzira inononoka uye isingatarisirwi. Kuburikidza nekuvandudzwa kweiyo lyophilization systems, matanho akawanda akagadziridzwa uye akacheneswa, achikurumidza kuita izvi.
